Formation of β-Substituted γ-Keto Esters via Zinc Carbenoid-Mediated Chain Extension

Authors

Weimin Lin, University of New HampshireFollow
Robert J. McGinness, University of New Hampshire
Emerald C. Wilson, University of New HampshireFollow
Charles K. Zercher, University of New HampshireFollow

Abstract

The conversion of β-keto esters into β-methylated γ-keto esters can be achieved through treatment with zinc carbenoids derived­ from 1,1-diiodoethane. The incorporation of a β-phenyl substituent is also possible through treatment with diiodotoluene

Department

Chemistry

Publication Date

1-1-2007

Journal Title

Synthesis

Publisher

Georg Thieme Verlag Stuttgart

Digital Object Identifier (DOI)

10.1055/s-2007-965886

Document Type

Article

Recommended Citation

Formation of Substituted g-Keto Esters via Zinc Carbenoid-Mediated Chain Extension, Lin, W.; McGinness, R. J.; Wilson, E.; Zercher, C. K. Synthesis, 2007, 2404-2408.

Rights

© Georg Thieme Verlag Stuttgart · New York