Chain Extension of Amino Acid Skeletons: Preparation of Ketomethylene Isosteres
Ketomethylene isosteric replacements for peptide bonds were generated through a zinc carbenoid-mediated chain extension reaction in which a variety of amino acid-derived β-keto esters are converted to γ-keto esters in a single step. The reaction tolerates a variety of protecting groups and amino acid side chains with no epimerization of the amino acid stereocenter.
Digital Object Identifier (DOI)
Chain Extension of Amino Acid Skeletons: Preparation of Ketomethylene Isosteres, Theberge, C. R.; Zercher, C. K. Tetrahedron 2003, 59, 1521-1527.
Copyright © 2003, Elsevier