Diamond Microelectrodes and CMOS Microelectronics for Wireless Transmission of Fast-Scan Cyclic Voltammetry
This paper reports on technology development at the sensor and circuit levels for wireless transmissionof fast- scan cyclic voltammetry (FSCV) in neurochemical detection. Heavily conductive, boron-dopeddiamond is selectively deposited onto the polished tip of a tungsten microelectrode to fabricate versatile, implantable, micro-needle microprobes capable of neurochemical sensing in the brain. In addition, an integrated circuit is fabricated in a 0.5-mum CMOS technology for processing and wirelesstransmission of the electrochemical signals corresponding to extracellular concentration changes of various neurotransmitters. The chip consists of a current-based, second-order, front-end SigmaDelta ADC and an on-chip, RF-FSK transmitter at the back-end. The ADC core and the transmitter consume 22 muA and 400 muA, respectively, from a 2.6-V power supply. Major electroactive neurotransmitters such as serotonin and dopamine in micromolar concentration have been wirelessly recorded at 433 MHz using 300-V/s FSCV in flow injection analysis experiments.
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Digital Object Identifier (DOI)
M. Roham, J. Halpern, H. Martin, H. Cheil, and P. Mohseni, ‘Diamond Microelectrodes and CMOS Microelectronics for Wireless Transmission of Fast-Scan Cyclic Voltammetry’, in 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2007, 2007, pp. pp. 6043–6046.